基本情況
劉君羊，男，中共黨員。五邑大學(xué)藥學(xué)與食品工程學(xué)院副教授，碩士研究生導(dǎo)師。
個(gè)人簡(jiǎn)介及研究方向
主要從事活性（海洋）天然產(chǎn)物的全合成、結(jié)構(gòu)修飾和構(gòu)效關(guān)系研究，完成了包括甾體、萜類(lèi)、大環(huán)內(nèi)脂類(lèi)、環(huán)肽類(lèi)等超過(guò)18個(gè)活性天然產(chǎn)物的全合成。歷年來(lái)主持國(guó)家自然科學(xué)基金面上基金、青年基金，國(guó)家重點(diǎn)實(shí)驗(yàn)室開(kāi)放課題項(xiàng)目、廣東省教育廳學(xué)科重點(diǎn)提升項(xiàng)目，深圳市面上項(xiàng)目等9項(xiàng)。目前在J. Am. Chem. Soc.、Chem、Green Syn. Catal.、Org. Lett.、Chinese J. Chem.、Org. Chem. Front.、Chem. Commun.、J. Org. Chem.、Nature Chemistry等國(guó)際刊物上發(fā)表研究論文38篇，其中以（共同）第一作者/（共同）通訊作者發(fā)表28篇，申請(qǐng)專(zhuān)利6項(xiàng)，授權(quán)2項(xiàng)。目前是廣東省藥理學(xué)會(huì)海洋藥物藥理專(zhuān)業(yè)委員會(huì)委員，國(guó)自然科學(xué)基金、廣東省基礎(chǔ)與應(yīng)用基礎(chǔ)研究基金項(xiàng)目評(píng)審專(zhuān)家，廣東省高層次人才評(píng)審專(zhuān)家，Chemical Science, RSC Advances, Marine Drugs等雜志審稿人。
聯(lián)系方式
地址：廣東省江門(mén)市蓬江區(qū)東成村22號(hào)五邑大學(xué)藥學(xué)與食品工程學(xué)院
郵編：529020
e-mail：[email protected]
工作經(jīng)歷
2022.02至今 ，五邑大學(xué)，藥學(xué)與食品工程學(xué)院，副教授，碩士生導(dǎo)師；
2017.12至2022.02，南方科技大學(xué)，高級(jí)研究學(xué)者、研究助理教授/研究副教授；2012.10至2017.11，北京大學(xué)、香港理工大學(xué)、南方科技大學(xué)，博士后/訪(fǎng)學(xué)；
教育及學(xué)習(xí)經(jīng)歷
2006.09-2012.01 北京大學(xué) 博士
2001.09-2005.07 南昌大學(xué) 本科
科研項(xiàng)目
1. 國(guó)家自然科學(xué)基金，面上項(xiàng)目，2024.01-2027.12，主持；
2. 國(guó)家自然科學(xué)基金，青年基金項(xiàng)目，2017.01-2019.12，主持；
3. 廣東省教育廳重點(diǎn)建設(shè)學(xué)科科研能力提升項(xiàng)目，2022.1-2024.12，主持；
4. 國(guó)家重點(diǎn)實(shí)驗(yàn)室，開(kāi)放課題項(xiàng)目，2023.1-2024.12，主持；
5. 深圳市科創(chuàng)委，面上項(xiàng)目，2020.06-2023.6，主持；
發(fā)表學(xué)術(shù)論文
1. Liu, Junyang; Wu, Jianlei; Fan, Jian-Hong; Yan, Xin; Mei, Guangjian; Li, Chuang-Chuang, Asymmetric Total Synthesis of Cyclocitrinol. J. Am. Chem. Soc. 2018, 140, (16), 5365-5369.
2. Liu, Xin#; Liu, Junyang#; Wu, Jianlei; Huang, Guocheng; Liang, Rong; Chung, Lung Wa; Li, Chuang-Chuang*, Asymmetric Total Synthesis of Cerorubenic Acid-III. J. Am. Chem. Soc. 2019, 141, (7), 2872-2877.
3. Liu, Junyang#; Liu, Xin#; Wu, Jianlei; Li, Chuang-Chuang*, Total Synthesis of Natural Products Containing a Bridgehead Double Bond. Chem 2020, 6, (3), 579-615.
4. Chen, Louxi; Zhang, Chao-Han; Liu, Junyang*; Sun, Jianwei*; Li, Chuang-Chuang*, Asymmetric Synthesis of the Tetracyclic Core of Venezuelaene B. Org. Lett. 2025, 27, (14), 3517-3520.
5. Chen, Louxi; Zhang, Chao-Han; Liu, Junyang*; Li, Chuang-Chuang*, Asymmetric synthesis of venezuelaene's core with a trans-fused [5-5] ring system. Chem. Commun. 2025, 61, (58), 10823-10826.
6. Feng, Jiaxuan; Liu, Junyang*; Ye, Tao, Total Synthesis, Stereochemical Assignment, and Structural Revision of HA 23. Org. Lett. 2025, 27, (33), 9299-9303.
7. Peng, Wenquan#; Han, Feipeng#; Liu, Junyang#; Wang, Chenqi; Minami, Atsushi; Oikawa, Hideaki; Guo, Yian; Ye, Tao, Thermolides D and E: Total Synthesis and Stereochemical Revision. Org. Lett. 2025, 27, (30), 8183-8188.
8. Wang, Chenqi; Liu, Junyang*; Ye, Tao*, Synergy of prediction rule and total synthesis in solving the stereochemical puzzle of eucalactam B. Org. Chem. Front. 2025, 12, (1), 70-75.
9. Jiang, Yangyang; Liu, Junyang*; Ye, Tao*, Total synthesis and stereochemical assignment of cubensci acid. Org. Chem. Front. 2025, 12, 4525–4529
10. Long, Xiong-En; Xing, Hailiang; He, Yixin; Meng, Xuanli; Ma, Yanling; Liu, Chang; Cao, Xi; Nan, Huiru; Cheng, Min-Jing*; Yan, Jia-Lei*; Liu, Junyang*, Total synthesis and biological evaluation of Koshidacin B, TAN-1746, and Ac-TAN-1746. BMC Chemistry 2025, 19, 213.
11. Liu, Haoyang; Xing, Hailiang; Yu, Peilan; Wang, Yanjie; Yan, Jia-Lei; Liu, Junyang*; Wang, Min*, Base-Controlled Synthesis of Heteroatom-Embedded 9-Membered Cycloalkynes and 6-Membered Sultams through Copper-Catalyzed Cyclization. J. Org. Chem. 2025, 90, (2), 984-993.
12. Nan, Huiru; Long, Xiong-En; He, Jianfei; Xing, Hailiang; Cheng, Min-Jing; Peng, Jin-Bao; Ye, Tao*; Yan, Jia-Lei*; Liu, Junyang*, Total Synthesis of the Marine Cyclic Depsipeptide Lagunamide D. Mar. Drugs 2025, 23, (3), 99.
13. Gu, Chen-Chen; Long, Xiong-En; Chen, Xiuping; Liu, Junyang*; Li, Chuang-Chuang*, Recent Natural Product Total Syntheses Involving Cycloadditions of Allenes. Chin. J. Chem. 2025, 43, (9), 1059-1077.
14. Liu, Junyang; Chen, Kai; Guo, Yian; Chen, Ying; Ye, Tao*, Total Synthesis of Rhizopodin Enabled by a Late-Stage Oxazole Ring Formation Strategy. Org. Lett. 2024, 26, (41), 8928-8933.
15. Yan, Jia-Lei; Nan, Huiru; Fang, Xiaoyu; Long, Xiong-En; Jiang, Yu; Liu, Junyang*, The isolation, bioactivity, and synthesis of natural products from Litsea verticillate with anti-HIV activities. Front. Pharmacol. 2024, 15, 1477878.
16. Xiao, Yi#; Liu, Junyang#; Jiang, Yangyang; Guo, Yian; Ye, Tao*, Total Syntheses and Stereochemical Assignment of Acremolides A and B. Molecules 2024, 29, (15), 3599.
17. Hou, Bao-Long*; Liu, Junyang*; Qiao, Chuang*; Li, Chuang-Chuang*, Total synthesis of natural products containing bicyclo[n.2.2] ring systems. Tetrahedron Lett. 2024, 135, 154871.
18. He, Yujie; Chen, Jintao; Jiang, Yu; Fang, Xiaoyu; Liu, Junyang*; Yan, Jia-Lei*, N-Heterocyclic Carbene Catalyzed Reactions Involving Acetylenic Breslow and/or Acylazolium as Key Intermediates. Chem. Rec. 2024, 24, (12), e202400165.
19. Liu, Junyang#; Tang, Shoubin#; Yan, Jia-Lei; Ye, Tao*, Design and Synthesis of Novel Helix Mimetics Based on the Covalent H-Bond Replacement and Amide Surrogate. Molecules 2023, 28, (2), 780.
20. Liu, Junyang; Chen, Hang; Wang, Min; He, Wangjin; Yan, Jia-Lei*, Organocatalytic asymmetric synthesis of P-stereogenic molecules. Front. Chem. 2023, 11.
21. Hui, Chunngai#, *; Wang, Zhuo#; Xie, Yusheng*; Liu, Junyang*, Contemporary synthesis of bioactive cyclobutane natural products. Green Synth. Catal. 2023, 4, (1), 1-6.
22. Liu, Junyang*; Chen, Ying; Luesch, Hendrik; Ye, Tao*, Total Synthesis of des-Thiomethyllooekeyolide A. Org. Lett. 2022, 24, (40), 7260-7264.
23. Wu, Jianlei#; Liu, Junyang#, *; Fan, Jian-Hong; Xie, Zhi-Dong; Qin, Hukun; Li, Chuang-Chuang*, Evolution of Routes for Asymmetric Total Synthesis of Cyclocitrinol Enabled by Type II [5+2] Cycloaddition?. Chin. J. Chem. 2021, 39, (5), 1247-1254.
24. Liu, Xin#; Liu, Junyang#; Wu, Jianlei; Li, Chuang-Chuang*, Enantioselective Total Synthesis of Cerorubenic Acid-III via Type II [5+2] Cycloaddition Reaction. J. Org. Chem. 2021, 86, (16), 11125-11139.
25. Liu, Xin#; Liu, Junyang#; Zhao, Jing; Li, Shaoping; Li, Chuang-Chuang*, Toward the Total Synthesis of Eurifoloid A. Org. Lett. 2017, 19, (10), 2742-2745.
26. Liu, Junyang; Wang, Lei; Zhang, Juefei; Xu, Zhengshuang*; Ye, Tao*, The total synthesis and stereochemical assignment of scytonemin A. Chem. Commun. 2016, 52, (5), 1002-1005.
27. Song, Liankai#; Liu, Junyang#; Gui, Honggang; Hui, Chunngai; Zhou, Jingjing; Guo, Yian; Zhang, Pengpeng; Xu, Zhengshuang*; Ye, Tao*, Synthesis of the Macrocyclic Core of Rhizopodin. Chem. - Asian J. 2013, 8, (12), 2955-2959.
28. Liu, Junyang; Ma, Xiao; Liu, Yuqing; Wang, Zhuo; Kwong, Shuqin; Ren, Qi; Tang, Shoubin; Meng, Yi; Xu, Zhengshuang*; Ye, Tao*, Total Synthesis and Stereochemical Revision of Burkholdac A. Synlett 2012, 23, (05), 783-787.
申請(qǐng)及授權(quán)專(zhuān)利
1. 劉君羊，南慧茹，龍雄恩，邢海亮，何健飛，馬艷玲，一種環(huán)肽 Lagunamide D 的制備方法，2024-12-30，中國(guó)，2024119701774。
2. 劉君羊，龍雄恩，南慧茹，邢海亮，劉昊洋，一種四環(huán)肽中間體化合物及其制備方法和應(yīng)用，2024-09-06，中國(guó)，202411250389.5。
3. 劉君羊，劉昊洋，邢海亮，王敏，一種六元環(huán)磺酰胺類(lèi)化合物的制備方法，2024-07-12，中國(guó)，202410937674（公開(kāi)）。
4. 劉君羊，景顯彤，陳婁曦，李闖創(chuàng)，虎皮楠生物堿骨架的合成方法，2022-02-11，中國(guó)，CN116621868A（公開(kāi)）。
5. 劉君羊，南慧茹，龍雄恩，閆加磊，一種化合物及其合成方法與在肌動(dòng)蛋白穩(wěn)定劑的合成方法中的應(yīng)用，2023-12-04，中國(guó)，ZL202311645681.2（授權(quán)）。
6. 劉君羊，吳建磊，范建紅，李闖創(chuàng)，甾體化合物的制備方法，2018-03-13，中國(guó)，ZL201810205745.X（授權(quán)）。
